News 2019 Polymyositis

 


Kurze deutsche Zusammenfassung:

Gute Nachrichten vom VHNK!

 

Es gibt Fortschritte in der Erforschung von Polymositis zu berichten. Es wurde eine Mutation gefunden die die Ursache der Erkrankung ist.

 

Das bedeutet, dass heterozygote und homozygote Tiere identifiziert werden können.

Aber diese Tiere müssen nicht unbedingt erkranken, da es sich um eine  Mutation handelt.

Daher gibt es noch keinen DNA Test.

 

Das Ziel der Universität Utrecht ist es jedoch die Gentypisierung aller Zuchttiere fertig zu stellen um mittels einer App (Fit2Breed) voraussichtlich  2020 erhältlich eine Risikobewertung zur Verfügung zu stellen.

 

Diese  Forschung wurde bisher großenteils durch Spenden aus aller Welt finanziert. (Weitere Spenden werden vom VHNK sicher gerne entgegen genommen - dafür kann ich gerne einen Kontakt herstellen)

 

Wir wissen jetzt von dieser Krankheit, dass mindestens ein genetischer Faktor für das Auftreten verantwortlich ist, sowie starke Umweltfaktoren oder vielleicht ein zweites Gen. 

In einem solchen Fall können Sie nicht mehr mit Konzepten wie "Träger" und "betroffen" arbeiten, sondern müssen für die vorgeschlagene Kombination eine Risikobewertung durchführen.

 

Mit dem Fit2Breed-Projekt erhalten wir auch SNP-Marker für das Kooikerhondje. Dies sind kleine Abweichungen in der DNA, die viele verschiedene Anwendungen haben. 

Mit diesen Markern können neue DNA-Tests entwickelt werden, aber auch die Bestimmung der Eltern, das Messen der genetischen Variation in einem einzelnen Hund und die Kombination von Elterntieren ("genetisches Matchmaking") sind möglich. 

 

Das Expertise Center Genetics of Companion Animals (ECGG) arbeitet derzeit intensiv an der Entwicklung des Softwaremoduls Fit2Breed. Neben dem Nederlandse Kooikerhondje ist der Labrador Retriever (nur in den Niederlanden) eine der beiden Rassen…..

 

Sobald ich weitere Informationen über diese Projekt habe, schreibe ich dies selbstverständlich wieder auf der Homepage!



 

Originaltext vom 13.4.2019 : 
Notification for website, club paper and foreign boards

 

The VHNK is happy to report on some important steps forward in the research around polymyositis.

A mutation has been found which is the cause off the illness. This means heterozygote and homozygote animals can be identified. However, this mutation does not cause all homozygote animals to become affected by the illness. As a result, the mutation does not differentiate between sick or healthy homozygote animals. Therefore, we cannot yet offer a DNA test that can specifically mark animals affected by the illness. 


At present the laboratory of Utrecht University (UU) is engaged with genotyping all breeding-animals. When completed, this will give the necessary information to come to a constructive method to avoid breeding Polymyositis cases. As soon as the Fit2Breed app is ready for use, a risk assessment will be available in the app. 


This research was supported by donations of Kooikerhondje clubs, breeders and individuals from all over the kooikerhondje-world. This project does not end with finding the mutation and the development of a risk assessment. Research will continue to find why animals do, or do not develop polymyositis. Therefore, it is important we continue to collect blood-samples of all breeding animals.

We are very glad about the collaboration with the University of Utrecht and will continue this into the future.


Fit2Breed App, estimated release 2020

We all have the purpose to breed dogs as healthy as possible. The breed clubs also have the purpose of maintaining the breed as a Nederlandse Kooikerhondje. To breed healthy dogs in a responsible and sustainable way, it is not only important to look at the individual combinations, but to consider the entire population.


A lot of data is already being collected, for example from clinical screenings for orthopedic disorders (Patella luxation) and eye disorders and the results of monogenetic DNA tests such as vWD and ENM. This data is often used on an individual basis to make male-female combinations and breeders use ZooEasy and the club register to look back on a number of generations of what occurs in their lines. 

It would be a pity if breeders would not consider the clinical data when planning a mating. 


At present, a source of concern for breeders is primarily polymyositis. We now know about this disease that at least one genetic factor is responsible for the occurrence, plus strong environmental factors or perhaps a second gene. In such a case you can no longer work with concepts such as "carrier" and "affected", but we must proceed with a risk assessment for the proposed combination.


With the Fit2Breed project we also get SNP markers for the Kooikerhondje. These are small variations in the DNA that have many different applications. With these markers new DNA tests can be developed, but also parental determination, measuring genetic variation in an individual dog and combining parent animals ("genetic matchmaking") are possible. The Expertise Centre Genetics of Companion Animals (ECGG) is currently working hard on developing the Fit2Breed software module. In addition to the Nederlandse Kooikerhondje, the Labrador Retriever (just in the Netherlands) is one of the two breeds 


for which Fit2Breed will be used first. With the Fit2Breed software it is possible to analyze all important data (disease data, results of screening examinations, risk estimates and breeding value estimates, results of monogenetic DNA tests and SNP data for genetic variety) and thus arrive at a scientifically supported breeding advice. For the breeder this means that he can fill in his female in the module, after which he gets a list of all males, sorted by suitability. It is also possible to enter a desired combination of a male and a female, whereby it is then indicated whether or not this combination is suitable. For the system to run as well as possible, it is very important that as much data as possible is entered into the system.


The Kooikerhondje, with all the data already collected and entered in the ZooEasy database, is very suitable for co-developing this software. Considering the overwhelming amount of known data for the kooikerhondje, a breeding program that uses only the pedigree data and calculates the mean kinship of animals, does not seem a suitable choice.

 

 
Cirtap`s Prins Finley van Minna-K
&
Cirtap`s Barones Lynn van Nilva-G
&
Askja Lynn van Crystalkooi


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